Interference of Fluorinated Anesthesia on 19F MRS of Fluorinated Drug Metabolism in Liver
نویسندگان
چکیده
Introduction: Fluorine (F) magnetic resonance spectroscopy (MRS) can monitor the concentration and metabolism of fluorinated cancer drugs like 5-fluorouracil (5-FU) and its oral prodrug capecitabine in vivo [1]. Previous F MRS animal studies of capecitabine and 5-FU metabolism used a variety of anesthetic agents including injectable fluorinated compounds like Hypnovel and Hypnorm [2]. Fluorinated inhalation anesthesia agents like isoflurane are very useful in MRS animal studies since they allow long experimental acquisitions (hours) while most intravenous anesthetics last about 30 minutes/dose. Yet there is concern that F spectra associated with fluorinated anesthesia (inhaled or injected) and their metabolites may interfere with the spectra from capecitabine and its metabolites. Therefore, we evaluated the effect of two common anesthetic agents, isoflurane and ketamine, on capecitabine liver metabolism in C57BL/6J mice using F MRS to determine interference between anesthetic and therapeutic agent.
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